Leader for a tb free world yang bertujuan pada pembangunan komitmen dalam mengakhiri tbc, tidak hanya pada kepala negara dan menteri tetapi juga di semua level baik bupati, gubernur, parlemen, pemimpin suatu komunitas, jajaran kesehatan, ngo, dan partner lainnya. Yang termasuk metode terbaru ini adalah metode fenotipik dan genotipik. The course contains seven modules and covers etiology and pathogenesis of tb, diagnosis and treatment, special situations. This set of tools is designed to help countries develop or strengthen a multidrugresistant tuberculosis mdrtb component within their national tb strategy. This mdr tb online course exists as a free selflearning online tool in allowing physicians worldwide to learn and test their knowledge of mdr tb.
Multi drug resistant tuberculosis mdr tb implications and diagnosis dr. Chapter 2 transmission and pathogenesis of tuberculosis cdc. Editor international union against tuberculosis and lung disease the union 68 boulevard st michel, 75006 paris, france suggested citation caminero ja, ed. Tb, tbhiv, and needs of vulnerable populations training for different health staff involved in the management of drmdr cases tot, tcstc. Diagnosis of drugresistant tb the new profile of drug. Untreated, mdrtb is a deadly disease affecting impoverished people who cannot afford timely diagnosis and adequate treatment for this curable illness. Multidrug resistant tuberculosis tbmdr adalah jenis resisten tb dengan resisten terhadap dua obat anti tuberculosis yang paling efektif yaitu rifampicin dan isoniazid. Tuberculosis is spread through the air when a person sneezes, coughs, or breathes. In one study conducted in the united states, 62% of hivinfected patients with mdrtb died during treatment compared to 26% of hiv infected patients with tb or without mdrtb 1. It has the second largest tuberculosis tb burden in the world with about 1 million new tb cases and is one of the top 10 highest multidrugresistant tb mdrtb countries globally. Vietnam is ranked 14th among 27 countries with high burden of multidrugresistant tuberculosis mdrtb. Extensively drug resistant tb xdr tb is a rare type of mdr tb that is resistant to isoniazid and rifampin, plus any fluoroquinolone and at least one of three injectable secondline drugs i.
Over 400,000 new cases of mdrtb occur each year and, although their rates. Management of contacts of mdr tb and xdr tb patients ecdc. Professor bengal college of pharmaceutical sciences and research 2. Provisional cdc guidelines for the use and safety monitoring of bedaquiline fumarate sirturo for the treatment of multidrugresistant tuberculosis. Mdr tuberculosis critical steps for prevention and control pdf. Multidrug resistant tuberculosis, somalia, 20102011. Two new drugs, bedaquiline and delamanid, have recently been released, and several new drugs and treatment regimens are in the pipeline. Tbc resistan obat adalah tbc yang disebabkan oleh kuman mycobacterium tuberculosis yang telah mengalami kekebalan terhadap oat multi drug resistant tuberculosis mdr tb atau tbc mdr adalah tbc resistan obat terhadap minimal 2 dua obat anti tbc yang paling poten yaitu inh dan. Management of contacts of mdr tb and xdr tb patients iii. To increase the access to mdrtb training globally, a pdf version of the course has. Pdf multidrugresistant tuberculosis mdrtb is an increasing global. Multidrugresistant tuberculosis and beyond european respiratory.
Multidrugresistant tuberculosis course multidrugresistant tuberculosis mdr tb is difficult to treat and there exists a significant lack of information about this infectious disease. What is extensively drug resistant tuberculosis xdr tb. Misuse of tb drugs is a principal cause of drug resistance. Provided by the centers for disease control and prevention cdc. Guidelines for clinical and operational management of drug. New guidelines and goals for treating mdrtb announced. As one of the major health and development partners in. A free powerpoint ppt presentation displayed as a flash slide show on id. Indonesia is ranked 8 of 27 countries with mdr tb in the world. Criteria for the control of drugresistant tuberculosis.
Mdr multidrugresistant mdrrrtb multidrugresistant tb or rifampicinresistant tb mdrtb multidrugresistant tb m. Sekitar 50 diantaranya adalah pasien tb bta positif. Vision an indonesia free of tuberculosis mission tb elimination in indonesia by 2030 national strategic plan 2016 2020 milestones toward tb elimination. Some forms of tb are also resistant to secondline medications, and are called extensively drugresistant tb. This is a pdf file of an unedited manuscript that has. F male to female ratio mic minimal inhibitory concentration mrna messenger rna naco national aids control organization ncd noncommunicable disease nfc near. Challenges in detection and treatment of multidrug. Ppt tuberculosis powerpoint presentation free to view. History of previous antitb treatment was the strongest independent factor for mdr tb odds ratio or 23. Agnes gebhard declared that she works for the kncv tb foundation, which has two projects funded by the eli lilly and company foundation. Saat ini indonesia juga menghadapi wabah corona virus covid19 yang juga menular melalui droplet.
Pdf pdf icon731 kb full guidelines pdf pdf icon 1 mb. Mdr tb multi drug resistant tuberculosis reversi baru sebesar 1,9% dan kasus mdr tb pada tb yang pernah diobati sebelumnya sebesar 17,1%, di kota makasar tahun 2007 data kasus mdr tb di antara kasus baru sebesar 4,1% dan kasus mdr tb pada tb yang pernah diobati sebelumnya sebesar 19,2%. Uncomplicated mdr tb is tb where the bacteria are only resistant to the first line drugs rifampicin and isoniazid the bangladesh regimen, together with the stream trial, are largely now of historical interest. Although effective tb drugs exist, improved treatments are being sought that are rapid acting, safe in combination with other disease therapies, and. Guidelines for clinical and operational management of drugresistant tuberculosis. Out of 580000 patients eligible for mdrtb treatment, only 125000 20%. Treatment of multidrugresistant tuberculosis mdrtb. Mdr tb is caused by mycobacterium tuberculosis that resistant to at least rifampicin and isoniazid. Presentations on the diagnosis of drugresistant tb addressed rapid diagnostic methods, the use of biochip technology, and the need for improved laboratory capacity. The management of drugresistant tb drtb is much more difficult than. In 2016, an estimated 600 000 new cases of mdr rr tb emerged globally. Mdrtb is produced by the selection of mdr strains resistant to at least isoniazid and rifampicin in patients who fail to complete chemotherapy with the correct combination of drugs.
Tb usually affects the lungs, but it can also affect other parts of the body, such as the brain, the kidneys, or the spine. Who consolidated guidelines on drugresistant tuberculosis treatment. The diagnosis of mdrtb can take several months or even longer often too late for the patient. Multi drug resistant mdr tb is the biggest problem of tb prevention and eradication in world. It is accredited by the south african medical association and the norwegian medical association. The emergence of multidrugresistant tuberculosis mdrtb and, more recently, extensively drugresistant tb xdrtb is widely considered a serious threat to global tb control. Donnelly 2 however, funding to stop the mdrtb epidemic has lagged well behind. Who treatment guidelines for drug resistant tuberculosis.
A policy framework on decentralised and deinstitutionalised management for south africa was coordinated by dr. Multidrugresistant tb mdr tb occurs when bacteria become resistant to at least the two firstline. Multidrugresistant tuberculosis mdrtb is a lifethreatening form of tb affecting half a million people. The most common form of the disease is tuberculosis of the lungs pulmonary consumption, or phthisis, but the intestines, bones and joints, the skin, and the genitourinary, lymphatic, and nervous systems may also be affected. Mdrtb planning toolkit introduction and users guide 3 mdrtb planning toolkit introduction and users guide. Participants in the gdg meeting on the who treatment guidelines for drugresistant tb 2016 update, 911 november 2015 49 appendix 2b. In 2009, the vietnamese government issued a policy on mdrtb called programmatic management of drugresistant tuberculosis pmdt to enhance and scale up diagnosis and treatment services for mdrtb. Multidrug resistant tuberculosis mdrtb is resistant to at least two of. Multidrugresistant tuberculosis mdrtb is defined as tuberculosis tb disease where there is in vitro resistance to both isoniazid and rifampicin, with or without resistance to. Pada banyak kasus, metode genotipik khususnya telah mendeteksi resistensi. Who global report 2010, estimated mdr tb patients in indonesia amounted to 8.
Indonesia current status of integrated community based tb. This mdrtb online course exists as a free selflearning online tool in. New guidelines for treating multidrug resistant tuberculosis mdrtb were announced at a gathering of tb experts in atlanta on may 10. Multidrugresistant tuberculosis mdrtb is a form of tuberculosis tb infection caused by. India mdr tb data state representative community based drug resistance surveys estimate the prevalence of multidrug resistant tb mdrtb to be 3% among new tb cases and 1217% among previouslytreated tb cases.
Tuberculosis tb is a disease caused by bacteria that are spread from person to person through the air. As new drugs and regimens reach the market, the need to make them available to patients. Multi drug resistant tb mdr tb didefinisikan sebagai resistensi terhadap dua agen anti tb lini pertama yang paling poten yaitu isoniazide inh dan rifampisin. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Longterm followup for multidrugresistant tuberculosis. Mdrtb country profile indonesia has a population of 254 million. Drugresistant tuberculosis diagnosis, treatment, management and control. Healthcare system factors influencing treatment results of. The bacteria that cause tuberculosis tb can develop resistance to the antimicrobial drugs used to cure the disease.
The strategy endorses the goal of increasing the number of mdrtb patients receiving treatment 50fold over the next decade. Manajemen terpadu pengendalian tb resistan obat mtptro definisi tbc resistan obat, tbc mdr dan tbc xdr. New treatments for multidrugresistant tuberculosis mdr tb are urgently needed. This book is a companion handbook to existing who policy guidance on the management of multidrugresistant tuberculosis, including the who guidelines for the programmatic management of drugresistant tuberculosis, who interim policy guidance on the use of bedaquiline in the treatment of multidrugresistant tuberculosis, and the who interim policy guidance on the use. Pdf pdf icon 37k multidrugresistant tuberculosis mdr tb what is tuberculosis tb. Multidrugresistant tuberculosis mdrtb is a form of tuberculosis tb infection caused by bacteria that are resistant to treatment with at least two of the most powerful firstline antitb medications drugs, isoniazid and rifampin. Multidrugresistant tuberculosis course wma the world. The bangladesh regimen is a short course 9 month regimen, for the treatment of uncomplicated mdr tb. Mdr multidrugresistant mdr rr tb multidrugresistant tb or rifampicinresistant tb mdr tb multidrugresistant tb m. Tuberculosis mdr tb 2017 update the latest anti tb drug resistance surveillance data show that 4. Little is known about the longterm followup of patients treated for mdrtb, including rates of relapse and chronic. This document was informed by the protocol for outpatient treatment of mdrtb, which was developed in january. The world health organization who developed the stop tb strategy and guidelines on how to prevent, control and treat mdr tb by using available data worldwide.
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